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Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapy

11 Jun 2024

Abstract excerpt

Multiple Myeloma (MM), a cancer of terminally differentiated plasma cells, is the second most prevalent hematological malignancy and is incurable due to the inevitable development of drug resistance. Intense protein synthesis is a distinctive trait of MM cells, supporting the massive production of clonal immunoglobulins or free light chains. The mammalian target of rapamycin (mTOR) kinase is appreciated as a...

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PMID: 38862983
DOI: 10.1186/s12964-024-01699-3

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