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Article

SLCO1B1: Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2021

Zhang Lingxin, Sarangi Vivekananda, Ho Ming-Fen, Moon Irene, Kalari Krishna R, Wang Liewei, Weinshilboum Richard M

Abstract excerpt

SLCO1B1 (solute carrier organic anion transporter family member 1B1) is an important transmembrane hepatic uptake transporter. Genetic variants in the SLCO1B1 gene have been associated with altered protein folding, resulting in protein degradation and decreased transporter activity. Next-generation sequencing (NGS) of pharmacogenes is being applied increasingly to associate variation in drug response with genetic...

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Identifiers

PMID: 33658230
DOI: 10.1124/dmd.120.000264
PMCID: PMC8042483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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