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Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (SLCO2B1).

Molecular pharmaceutics - 5 Oct 2020

Yang Jingjie, Wang Zhongmin, Liu Shuai, Wang Weipeng, Zhang Hongjian, Gui Chunshan

Abstract excerpt

The organic anion transporting polypeptide 2B1 (OATP2B1), which is encoded by the SLCO2B1 gene, plays important roles in the absorption and disposition of its substrate drugs. Nonsynonymous variations of SLCO2B1 change its amino acid sequence and may alter its function. However, so far, very few genetic variants of SLCO2B1 have been functionally characterized. In the present study, first of all, 14 nonsynonymous...

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Cell Membrane
HEK293 Cells
Mutagenesis, Site-Directed
Organic Anion Transporters
Pharmacogenomic Variants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Recombinant Proteins

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PMID: 32902299
DOI: 10.1021/acs.molpharmaceut.0c00747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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