Article
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells.
The Journal of experimental medicine - 5 Apr 2021
Lucca Liliana E, Axisa Pierre-Paul, Lu Benjamin, Harnett Brian, Jessel Shlomit, Zhang Le, Raddassi Khadir, Zhang Lin, Olino Kelly, Clune James, Singer Meromit, Kluger Harriet M, Hafler David A
Abstract excerpt
Understanding the relationship between tumor and peripheral immune environments could allow longitudinal immune monitoring in cancer. Here, we examined whether T cells that share the same TCRαβ and are found in both tumor and blood can be interrogated to gain insight into the ongoing tumor T cell response. Paired transcriptome and TCRαβ repertoire of circulating and tumor-infiltrating T cells were analyzed at the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.