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Individual and Joint Associations of Genetic Risk and Healthy Lifestyle Score with Colorectal Neoplasms Among Participants of Screening Colonoscopy.

Cancer prevention research (Philadelphia, Pa.) - 1 Jun 2021

Erben Vanessa, Carr Prudence R, Guo Feng, Weigl Korbinian, Hoffmeister Michael, Brenner Hermann

Abstract excerpt

Genetic and lifestyle factors contribute to colorectal cancer risk. We investigated their individual and joint associations with various stages of colorectal carcinogenesis. We assessed associations of a polygenic risk score (PRS) and a healthy lifestyle score (HLS) with presence of nonadvanced adenomas and advanced neoplasms among 2,585 participants of screening colonoscopy from Germany. The PRS and HLS...

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PMID: 33653736
DOI: 10.1158/1940-6207.CAPR-20-0576

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