Estimating the heritability of colorectal cancer.

doi:10.1093/hmg/ddu087

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Article

Estimating the heritability of colorectal cancer.

Human molecular genetics - 15 Jul 2014

Jiao Shuo, Peters Ulrike, Berndt Sonja, Brenner Hermann, Butterbach Katja, Caan Bette J, Carlson Christopher S, Chan Andrew T, Chang-Claude Jenny, Chanock Stephen, Curtis Keith R, Duggan David, Gong Jian, Harrison Tabitha A, Hayes Richard B, Henderson Brian E, Hoffmeister Michael, Kolonel Laurence N, Le Marchand Loic, Potter John D, Rudolph Anja, Schoen Robert E, Seminara Daniela, Slattery Martha L, White Emily, Hsu Li

Abstract excerpt

A sizable fraction of colorectal cancer (CRC) is expected to be explained by heritable factors, with heritability estimates ranging from 12 to 35% twin and family studies. Genome-wide association studies (GWAS) have successfully identified a number of common single-nucleotide polymorphisms (SNPs) associated with CRC risk. Although it has been shown that these CRC susceptibility SNPs only explain a small...

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PMID: 24562164
DOI: 10.1093/hmg/ddu087
PMCID: PMC4065150

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