Article
Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.
Neurology - 25 Jul 2023
Fang Yi, Si Xiaoli, Wang Jiali, Wang Zhiyun, Chen Ying, Liu Yi, Yan Yaping, Tian Jun, Zhang Baorong, Pu Jiali
Abstract excerpt
BACKGROUND AND OBJECTIVES: Observational studies suggested a bidirectional relationship between Alzheimer disease (AD) and epilepsies. However, it remains debated whether and in which direction a causal association exists. This study aims to explore the relationship between genetic predisposition to AD, CSF biomarkers of AD (β-amyloid [Aβ] 42 and phosphorylated tau [pTau]), and epilepsies with 2-sample,...
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