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Article

Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis.

PLoS medicine - 1 Sept 2014

Proitsi Petroula, Lupton Michelle K, Velayudhan Latha, Newhouse Stephen, Fogh Isabella, Tsolaki Magda, Daniilidou Makrina, Pritchard Megan, Kloszewska Iwona, Soininen Hilkka, Mecocci Patrizia, Vellas Bruno, Williams Julie, Stewart Robert, Sham Pak, Lovestone Simon, Powell John F

Abstract excerpt

BACKGROUND: Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol and AD pathology are still not well understood and contradictory...

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Identifiers

PMID: 25226301
DOI: 10.1371/journal.pmed.1001713
PMCID: PMC4165594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25226301-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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