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Loss of SHMT2 mediates 5-FU chemoresistance by inducing autophagy in colorectal cancer

2019-06-24

Abstract excerpt

Serine hydroxymethyltransferase 2 (SHMT2) plays a vital role in one-carbon metabolism and drives colorectal carcinogenesis. In our study, loss of SHMT2 induced 5-Fluorouracil (5-FU) chemoresistance and was associated with poor prognosis in colorectal cancer (CRC). To elucidate the possible mechanism and generate a strategy to sensitize CRC to 5-FU chemotherapy, we first identified the binding proteins of SHMT2 in...

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Literature Corpus work
c2aac898-eefa-5742-a764-667c75f0aada
DOI
10.1101/680892
Open publication

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Loss of SHMT2 mediates 5-FU chemoresistance by inducing autophagy in colorectal cancerDOI 10.1101/680892
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