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Article

Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.

PLoS genetics - 13 Jun 2008

Chen Peng-Chieh, Kuraguchi Mari, Velasquez John, Wang Yuxun, Yang Kan, Edwards Robert, Gillen Dan, Edelmann Winfried, Kucherlapati Raju, Lipkin Steven M

Abstract excerpt

DNA mismatch repair suppresses gastrointestinal tumorgenesis. Four mammalian E. coli MutL homologues heterodimerize to form three distinct complexes: MLH1/PMS2, MLH1/MLH3, and MLH1/PMS1. To understand the mechanistic contributions of MLH3 and PMS2 in gastrointestinal tumor suppression, we generated Mlh3(-/-);Apc(1638N) and Mlh3(-/-);Pms2(-/-);Apc(1638N) (MPA) mice. Mlh3 nullizygosity significantly increased Apc...

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Share to Adenomatous Polyposis Coli Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18551179
DOI: 10.1371/journal.pgen.1000092
PMCID: PMC2410297

Genes

MLH1
RUNX3
MLH3
PMS1
PMS2
TLE6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.PMID 18551179Read ↗

Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.Semantic proximity Read ↗

The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.Semantic proximity Read ↗

The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.Semantic proximity Read ↗

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.Semantic proximity Read ↗

Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestineSemantic proximity Read ↗

Expression of the MutL Homologue hMLH3 in Human Cells and its Role in DNA Mismatch RepairSemantic proximity Read ↗

Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processesSemantic proximity Read ↗

Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal CancerSemantic proximity Read ↗

MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.Semantic proximity Read ↗

Tissue-specific reduction in MLH1 expression induces microsatellite instability in intestine of Mlh1 miceSemantic proximity Read ↗

MSH3-Deficiency Initiates EMAST without Oncogenic Transformation of Human Colon Epithelial CellsSemantic proximity Read ↗

<i>Mlh1</i> haploinsufficiency induces microsatellite instability specifically in intestineSemantic proximity Read ↗

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