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RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer

30 Apr 2025

Abstract excerpt

Introduction Immune checkpoint blockade (ICB) therapy has shown promise in treating advanced colorectal cancer, particularly in patients with microsatellite instability-high (MSI-H) tumors. However, only a subset of these patients responds favorably, highlighting the need for strategies to improve immunotherapy efficacy. Methods To identify potential regulators of immunotherapy response, we conducted a...

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PMID: 40370450
DOI: 10.3389/fimmu.2025.1515568

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