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Article

Stem cell models help crack regional oncohistone codes driving childhood gliomas.

Cell stem cell - 6 May 2021

Klein Rachel H, Knoepfler Paul S

Abstract excerpt

In this issue of Cell Stem Cell, Funato et al. (2021) and Bressan et al. (2021) use stem cells as models to define functions of the histone H3.3 G34R mutation in childhood gliomas. Both studies find strong regional specificity to oncohistone activity and implicate specific elements of an aberrantly locked-in neural progenitor transcriptional circuitry.

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Identifiers

PMID: 33961758
DOI: 10.1016/j.stem.2021.04.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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