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Article

A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation.

Molecular cell - 15 Apr 2021

Regadas Isabel, Dahlberg Olle, Vaid Roshan, Ho Oanh, Belikov Sergey, Dixit Gunjan, Deindl Sebastian, Wen Jiayu, Mannervik Mattias

Abstract excerpt

Organismal development and cell differentiation critically depend on chromatin state transitions. However, certain developmentally regulated genes lack histone 3 lysine 9 and 27 acetylation (H3K9ac and H3K27ac, respectively) and histone 3 lysine 4 (H3K4) methylation, histone modifications common to most active genes. Here we describe a chromatin state featuring unique histone 3 lysine 14 acetylation (H3K14ac)...

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PMID: 33631105
DOI: 10.1016/j.molcel.2021.01.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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