Article
Flow cytometric immunophenotypic alterations of persistent clonal haematopoiesis in remission bone marrows of patients with NPM1-mutated acute myeloid leukaemia.
British journal of haematology - 1 Mar 2021
Loghavi Sanam, DiNardo Courtney D, Furudate Ken, Takahashi Koichi, Tanaka Tomoyuki, Short Nicholas J, Kadia Tapan, Konopleva Marina, Kanagal-Shamanna Rashmi, Farnoud Noushin R, Pierce Sherry, Khoury Joseph D, Jorgensen Jeffrey L, Patel Keyur P, Daver Naval, Yilmaz Musa, Medeiros L Jeffrey, Kantarjian Hagop, Ravandi Farhad, Wang Sa A
Abstract excerpt
Clonal haematopoiesis (CH) in patients with acute myeloid leukaemia (AML) may persist beyond attaining complete remission. From a consecutive cohort of 67 patients with nucleophosmin 1-mutated (NPM1mut ) AML, we identified 50 who achieved NPM1mut clearance and had parallel multicolour flow cytometry (MFC) and next generation sequencing (NGS). In total, 13 (26%) cleared all mutations, 37 (74%) had persistent CH...
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