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Article

Prognostic impact of clonal hematopoiesis mutations at complete molecular remission in acute myeloid leukemia with NPM1 mutation.

Journal of cancer research and clinical oncology - 18 Oct 2024

Wang Linlin, Shu Mingkai, Zhang Zhibo, Dou Xueqing, Xu Xiaoyu, Ma Yanan, Wen Lijun, Yang Xiaofei, Chen Suning

Abstract excerpt

The prognostic impact of clonal hematopoiesis (CH) in complete molecular remission (CMR) in acute myeloid leukemia (AML) remains controversial. Here, we explored the prognosis of CH-related gene mutations (CH-mutation) at CMR in patients with AML with NPM1 mutation (NPM1c AML). Ninety-one patients with de novo NPM1c AML were included between June 2018 and June 2023, including 32 patients with CH-related mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39422784
DOI: 10.1007/s00432-024-05999-6
PMCID: PMC11489237

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