Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenine Base Editor Ribonucleoproteins Delivered by Lentivirus-Like Particles Show High On-Target Base Editing and Undetectable RNA Off-Target Activities.

The CRISPR journal - 1 Feb 2021

Lyu Pin, Lu Zuyan, Cho Sung-Ik, Yadav Manish, Yoo Kyung Whan, Atala Anthony, Kim Jin-Soo, Lu Baisong

Abstract excerpt

Adenine base editors (ABEs) can correct gene mutations without creating double-strand breaks. However, in recent reports, these editors showed guide-independent RNA off-target activities. This work describes our development of a delivery method to minimize ABEs' RNA off-target activity. After discovering a RNA off-target hot spot for sensitive detection of RNA off-target activities, we found that delivering...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine
Share to Aptamers, Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capsid

Share to Gene Editing

Share to Lentivirus

Share to Ribonucleoproteins

Share to RNA Editing

Source

Identifiers

PMID: 33616436
DOI: 10.1089/crispr.2020.0095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenine Base Editor Ribonucleoproteins Delivered by Lentivirus-Like Particles Show High On-Target Base Editing and Undetectable RNA Off-Target Activities.PMID 33616436Read ↗

Targeted RNA base editing for therapeutic: mechanisms and advancesSemantic proximity Read ↗

Engineering a precise adenine base editor with minimal bystander editing.Semantic proximity Read ↗

Engineering precise adenine base editor with infinitesimal rates of bystander mutations and off-target editingSemantic proximity Read ↗

High-purity production and precise editing of DNA base editing ribonucleoproteinsSemantic proximity Read ↗

High-fidelity base editor with no detectable genome-wide off-target effectsSemantic proximity Read ↗

Analysis and minimization of cellular RNA editing by DNA adenine base editorsSemantic proximity Read ↗

Breaking genetic shackles: The advance of base editing in genetic disorder treatmentSemantic proximity Read ↗

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope.Semantic proximity Read ↗

CRISPR-Cas9 DNA Base-Editing and Prime-Editing.Semantic proximity Read ↗

Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA.Semantic proximity Read ↗

Design and application of the transformer base editor in mammalian cells and mice.Semantic proximity Read ↗

An integrated enzymatic and computational pipeline for quantifying off-target base-editingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.