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Article

High-resolution HLA typing by long reads from the R10.3 Oxford nanopore flow cells.

Human immunology - 1 Apr 2021

Liu Chang, Yang Xiao, Duffy Brian F, Hoisington-Lopez Jessica, Crosby MariaLynn, Porche-Sorbet Rhonda, Saito Katsuyuki, Berry Rick, Swamidass Victoria, Mitra Robi D

Abstract excerpt

Nanopore sequencing has been investigated as a rapid and cost-efficient option for HLA typing in recent years. Despite the lower raw read accuracy, encouraging typing accuracy has been reported, and long reads from the platform offer additional benefits of the improved phasing of distant variants. The newly released R10.3 flow cells are expected to provide higher read-level accuracy than previous chemistries. We...

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PMID: 33612390
DOI: 10.1016/j.humimm.2021.02.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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