2.7 million samples genotyped for HLA by next generation sequencing: lessons learned.

doi:10.1186/s12864-017-3575-z

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Article

2.7 million samples genotyped for HLA by next generation sequencing: lessons learned.

BMC genomics - 14 Feb 2017

Schöfl Gerhard, Lang Kathrin, Quenzel Philipp, Böhme Irina, Sauter Jürgen, Hofmann Jan A, Pingel Julia, Schmidt Alexander H, Lange Vinzenz

Abstract excerpt

BACKGROUND: At the DKMS Life Science Lab, Next Generation Sequencing (NGS) has been used for ultra-high-volume high-resolution genotyping of HLA loci for the last three and a half years. Here, we report on our experiences in genotyping the HLA, CCR5, ABO, RHD and KIR genes using a direct amplicon...

Topics

Alleles
Computational Biology
Genotype
Genotyping Techniques
HLA Antigens
High-Throughput Nucleotide Sequencing
Humans
Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 28196473
DOI: 10.1186/s12864-017-3575-z
PMCID: PMC5309984

Genes

ABO
CCR5
RHD

Provenance

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-28196473-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.