Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development.

Blood cancer journal - 10 Apr 2015

Smith E N, Ghia E M, DeBoever C M, Rassenti L Z, Jepsen K, Yoon K-A, Matsui H, Rozenzhak S, Alakus H, Shepard P J, Dai Y, Khosroheidari M, Bina M, Gunderson K L, Messer K, Muthuswamy L, Hudson T J, Harismendy O, Barrett C L, Jamieson C H M, Carson D A, Kipps T J, Frazer K A

Abstract excerpt

We examined genetic and epigenetic changes that occur during disease progression from indolent to aggressive forms of chronic lymphocytic leukemia (CLL) using serial samples from 27 patients. Analysis of DNA mutations grouped the leukemia cases into three categories: evolving (26%), expanding (26...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Evolution
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Mutation

Share to Polycomb-Group Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25860294
DOI: 10.1038/bcj.2015.14
PMCID: PMC4450323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25860294-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development.PMID 25860294Read ↗

Evolution of DNA Methylation Is Linked to Genetic Aberrations in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Molecular pathogenesis of CLL and its evolution.Semantic proximity Read ↗

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.Semantic proximity Read ↗

Genetics and epigenetics of CLL.Semantic proximity Read ↗

Genetic and epigenetic basis of chronic lymphocytic leukemia.Semantic proximity Read ↗

The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemiaSemantic proximity Read ↗

Mutations driving CLL and their evolution in progression and relapse.Semantic proximity Read ↗

Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and TherapySemantic proximity Read ↗

Advances in epigenetic alterations of chronic lymphocytic leukemia: from pathogenesis to treatmentSemantic proximity Read ↗

Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia.Semantic proximity Read ↗

Chronic lymphocytic leukaemia genomics and the precision medicine era.Semantic proximity Read ↗

Longitudinal genome-wide analysis of patients with chronic lymphocytic leukemia reveals complex evolution of clonal architecture at disease progression and at the time of relapseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.