Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.

doi:10.1016/j.ccell.2014.10.012

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Article

Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.

Cancer cell - 8 Dec 2014

Landau Dan A, Clement Kendell, Ziller Michael J, Boyle Patrick, Fan Jean, Gu Hongcang, Stevenson Kristen, Sougnez Carrie, Wang Lili, Li Shuqiang, Kotliar Dylan, Zhang Wandi, Ghandi Mahmoud, Garraway Levi, Fernandes Stacey M, Livak Kenneth J, Gabriel Stacey, Gnirke Andreas, Lander Eric S, Brown Jennifer R, Neuberg Donna, Kharchenko Peter V, Hacohen Nir, Getz Gad, Meissner Alexander, Wu Catherine J

Abstract excerpt

Intratumoral heterogeneity plays a critical role in tumor evolution. To define the contribution of DNA methylation to heterogeneity within tumors, we performed genome-scale bisulfite sequencing of 104 primary chronic lymphocytic leukemias (CLLs). Compared with 26 normal B cell samples, CLLs consistently displayed higher intrasample variability of DNA methylation patterns across the genome, which appears to arise...

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Identifiers

PMID: 25490447
DOI: 10.1016/j.ccell.2014.10.012
PMCID: PMC4302418

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