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Article

IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes

13 Jan 2011

Abstract excerpt

Robust and rapid induction of interferon-β (IFN-β) in monocytes after pathogenic stimulation is a hallmark of innate immune responses. Here, we reveal the molecular mechanism underlying this key property that is exclusive to human blood monocytes. We found that IFN-β was produced rapidly in primary human monocytes as a result of cooperation between the myeloid-specific transcription factor IRF8 and the ubiquitous...

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PMID: 21228327
DOI: 10.1182/blood-2010-07-294272

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