Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients.

doi:10.1038/s41598-021-83762-4

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Article

Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients.

Scientific reports - 18 Feb 2021

Cortese Maria Francesca, González Carolina, Gregori Josep, Casillas Rosario, Carioti Luca, Guerrero-Murillo Mercedes, Riveiro-Barciela Mar, Godoy Cristina, Sopena Sara, Yll Marçal, Quer Josep, Rando Ariadna, Lopez-Martinez Rosa, Pacín Ruiz Beatriz, García-García Selene, Esteban-Mur Rafael, Tabernero David, Buti Maria, Rodríguez-Frías Francisco

Abstract excerpt

Patients with HBeAg-negative chronic infection (CI) have not been extensively studied because of low viremia. The HBx protein, encoded by HBX, has a key role in viral replication. Here, we analyzed the viral quasispecies at the 5' end of HBX in CI patients and compared it with that of patients in other clinical stages. Fifty-eight HBeAg-negative patients were included: 16 CI, 19 chronic hepatitis B, 16...

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Identifiers

PMID: 33603102
DOI: 10.1038/s41598-021-83762-4
PMCID: PMC7892877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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