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Article

Characterization of BCP/PreC/C region quasispecies in treatment-naive patients with different phases of HBV infection using next-generation sequencing.

International journal of medical microbiology : IJMM - 1 Jun 2024

Zhu Chenggong, Tang Minjie, Fu Ya, Xun Zhen, Lin Caorui, Wu Songhang, Chen Tianbin, Zeng Yongbin, Yang Bin, Ou Qishui, Liu Can

Abstract excerpt

BACKGROUND: To analysis of quasispecies (QS) changes and high-frequency mutations in the BCP/PreC/C region of patients at different phases of hepatitis B virus (HBV) infection and provides novel biomarkers for the diagnosis of chronic hepatitis B (CHB) patients. METHODS: With the application of next-generation sequencing technology, we were able to sequence the HBV BCP/PreC/C regions in 40 patients, each at...

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PMID: 38564936
DOI: 10.1016/j.ijmm.2024.151619

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