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Article

Beta-adrenergic regulation of the heart expressing the Ser1700A/Thr1704A mutated Cav1.2 channel.

Journal of molecular and cellular cardiology - 1 Oct 2017

Poomvanicha Montatip, Matthes Jan, Domes Katrin, Patrucco Enrico, Angermeier Elisabeth, Laugwitz Karl-Ludwig, Schneider Toni, Hofmann Franz

Abstract excerpt

Beta-adrenergic stimulation of the heart increases ICa. PKA dependent phosphorylation of several amino acids (among them Ser 1700 and Thr 1704 in the carboxy-terminus of the Cav1.2 α1c subunit) has been implicated as decisive for the β-adrenergic up-regulation of cardiac ICa. Mutation of Ser 1700 and Thr 1704 to alanine results in the Cav1.2PKA_P2-/- mice. Cav1.2PKA_P2-/- mice display reduced cardiac L-type...

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PMID: 28778765
DOI: 10.1016/j.yjmcc.2017.07.119

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