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Article

β-adrenergic regulation of the L-type Ca2+ channel does not require phosphorylation of α1C Ser1700.

Circulation research - 13 Sept 2013

Yang Lin, Katchman Alexander, Samad Tahmina, Morrow John, Weinberg Richard, Marx Steven O

Abstract excerpt

RATIONALE: Sympathetic nervous system triggered activation of protein kinase A, which phosphorylates several targets within cardiomyocytes, augments inotropy, chronotropy, and lusitropy. An important target of β-adrenergic stimulation is the sarcolemmal L-type Ca(2+) channel, CaV1.2, which plays a key role in cardiac excitation-contraction coupling. The molecular mechanisms of β-adrenergic regulation of CaV1.2 in...

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Identifiers

PMID: 23825359
DOI: 10.1161/CIRCRESAHA.113.301926
PMCID: PMC3864014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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