Article
Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice.
The Journal of biological chemistry - 12 Dec 2008
Lemke Toni, Welling Andrea, Christel Carl Johannes, Blaich Anne, Bernhard Dominik, Lenhardt Peter, Hofmann Franz, Moosmang Sven
Abstract excerpt
Phosphorylation of serine 1928 (Ser(1928)) of the cardiac Ca(v)1.2 subunit of L-type Ca(2+) channels has been proposed as the mechanism for regulation of L-type Ca(2+) channels by protein kinase A (PKA). To test this directly in vivo, we generated a knock-in mouse with targeted mutation of Ser(1928) to alanine. This mutation did not affect basal L-type current characteristics or regulation of the L-type current...
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