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Article

A novel role for Dun1 in the regulation of origin firing upon hyper-acetylation of H3K56.

PLoS genetics - 1 Feb 2021

Gershon Lihi, Kupiec Martin

Abstract excerpt

During DNA replication newly synthesized histones are incorporated into the chromatin of the replicating sister chromatids. In the yeast Saccharomyces cerevisiae new histone H3 molecules are acetylated at lysine 56. This modification is carefully regulated during the cell cycle, and any disruption of this process is a source of genomic instability. Here we show that the protein kinase Dun1 is necessary in order...

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Identifiers

PMID: 33600490
DOI: 10.1371/journal.pgen.1009391
PMCID: PMC7924802

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