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Article

Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.

Genetics - 1 Aug 2008

Celic Ivana, Verreault Alain, Boeke Jef D

Abstract excerpt

Deacetylation of histone H3 K56, regulated by the sirtuins Hst3p and Hst4p, is critical for maintenance of genomic stability. However, the physiological consequences of a lack of H3 K56 deacetylation are poorly understood. Here we show that cells lacking Hst3p and Hst4p, in which H3 K56 is constitutively hyperacetylated, exhibit hallmarks of spontaneous DNA damage, such as activation of the checkpoint kinase...

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Identifiers

PMID: 18579506
DOI: 10.1534/genetics.108.088914
PMCID: PMC2516057

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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