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Article

Partitioning of parental histones between leading and lagging strands is modulated by DNA polymerase dosage.

Nucleic acids research - 10 Aug 2026

Dickinson Quinn, Karri Srinivasu, Kenmogne Odile Djom, Zhu Shuang, Rivera-Mulia Juan Carlos, Ye Zhenqing, Wang Zhiquan, Gan Haiyun, Yu Chuanhe

Abstract excerpt

Epigenetic inheritance relies on the precise recycling of parental histones during DNA replication. The N-terminal region of Pol1, the catalytic subunit of DNA polymerase α, has previously been implicated in chaperoning parental histone recycling. In this study, we identify a single amino acid mutation in the C-terminal region of Saccharomyces cerevisiae Pol1 (pol1-F1396S) that destabilizes the protein and...

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Identifiers

PMID: 42581759
DOI: 10.1093/nar/gkag787
PMCID: PMC13462271

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