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Article

CD4+ T cells from children with active juvenile idiopathic arthritis show altered chromatin features associated with transcriptional abnormalities.

Scientific reports - 17 Feb 2021

Tarbell Evan, Jiang Kaiyu, Hennon Teresa R, Holmes Lucy, Williams Sonja, Fu Yao, Gaffney Patrick M, Liu Tao, Jarvis James N

Abstract excerpt

Juvenile idiopathic arthritis (JIA) is one of the most common chronic diseases in children. While clinical outcomes for patients with juvenile JIA have improved, the underlying biology of the disease and mechanisms underlying therapeutic response/non-response are poorly understood. We have shown that active JIA is associated with distinct transcriptional abnormalities, and that the attainment of remission is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33597588
DOI: 10.1038/s41598-021-82989-5
PMCID: PMC7889855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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