Article

Identification of causal genes and mechanisms by which genetic variation mediates juvenile idiopathic arthritis susceptibility using functional genomics and CRISPR-Cas9

2025-05-22

Abstract excerpt

<h4>Objective</h4> Genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with juvenile idiopathic arthritis (JIA), the majority of which are located in non-coding regions such as enhancers. This presents a challenge for pinpointing causal variants and their target genes. Interpreting these loci requires functional genomics data from disease-relevant tissu...

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Literature Corpus work: d6c56673-f2ca-5d01-bd54-3f93e2fdf517
DOI: 10.1101/2025.05.22.25325739

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