Article
The Multi-Omics Architecture of Juvenile Idiopathic Arthritis.
Cells - 15 Oct 2020
Hou Xiaoyuan, Qu Huiqi, Zhang Sipeng, Qi Xiaohui, Hakonarson Hakon, Xia Qianghua, Li Jin
Abstract excerpt
Juvenile idiopathic arthritis (JIA) is highly heterogeneous in terms of etiology and clinical presentation with ambiguity in JIA classification. The advance of high-throughput omics technologies in recent years has gained us significant knowledge about the molecular mechanisms of JIA. Besides a minor proportion of JIA cases as monogenic, most JIA cases are polygenic disease caused by autoimmune mechanisms. A...
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