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Article

Functional Characteristics and Phenotypic Plasticity of CD57+PD1- CD4 T Cells and Their Relationship with Transplant Immunosuppression.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2021

Shaw Brian I, Espinosa Jaclyn R, Stempora Linda, Miller Allison, Adams Bartley, Kirk Allan D

Abstract excerpt

Costimulation blockade (CoB)-based immunosuppression offers the promise of improved transplantation outcomes with reduced drug toxicity. However, it is hampered by early acute rejections, mediated at least in part by differentiated, CoB-resistant T cells, such as CD57+PD1- CD4 T cells. In this study, we characterize these cells pretransplant, determine their fate posttransplant, and examine their proliferative...

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Identifiers

PMID: 33597150
DOI: 10.4049/jimmunol.2000736
PMCID: PMC7987798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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