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Donor HLA-DQ reactive B cells clonally expand under chronic immunosuppression and include atypical CD21 <sup>low</sup> CD27 <sup>−</sup> B cells with high-avidity germline B-cell receptors

2024-12-10

Abstract excerpt

Long-term allograft survival is limited by humoral-associated chronic allograft rejection, suggesting inadequate constraint of humoral alloimmunity by contemporary immunosuppression. Heterogeneity in alloreactive B cells and the incomplete definition of which B cells participate in chronic rejection in immunosuppressed transplant recipients limits our ability to develop effective therapies. Using a double-fluoroch...

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Literature Corpus work
ef6d0b60-d26d-51a1-a73c-ccdeba5ceacd
DOI
10.1101/2024.12.06.627284
Open publication

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Donor HLA-DQ reactive B cells clonally expand under chronic immunosuppression and include atypical CD21 <sup>low</sup> CD27 <sup>−</sup> B cells with high-avidity germline B-cell receptorsDOI 10.1101/2024.12.06.627284
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