Article
CMV-Responsive CD4 T Cells Have a Stable Cytotoxic Phenotype Over the First Year Post-Transplant in Patients Without Evidence of CMV Viremia.
Frontiers in immunology - 1 Jan 2022
Higdon Lauren E, Ahmad Ayah A, Schaffert Steven, Margulies Kenneth B, Maltzman Jonathan S
Abstract excerpt
Cytomegalovirus (CMV) infection is a known cause of morbidity and mortality in solid organ transplant recipients. While primary infection is controlled by a healthy immune system, CMV is never eradicated due to viral latency and periodic reactivation. Transplantation and associated therapies hinder immune surveillance of CMV. CD4 T cells are an important part of control of CMV reactivation. We therefore...
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