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Article

The Impact of Purifying and Background Selection on the Inference of Population History: Problems and Prospects.

Molecular biology and evolution - 25 Jun 2021

Johri Parul, Riall Kellen, Becher Hannes, Excoffier Laurent, Charlesworth Brian, Jensen Jeffrey D

Abstract excerpt

Current procedures for inferring population history generally assume complete neutrality-that is, they neglect both direct selection and the effects of selection on linked sites. We here examine how the presence of direct purifying selection and background selection may bias demographic inference by evaluating two commonly-used methods (MSMC and fastsimcoal2), specifically studying how the underlying shape of the...

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Identifiers

PMID: 33591322
DOI: 10.1093/molbev/msab050
PMCID: PMC8233493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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