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Article

Allele ages provide limited information about the strength of negative selection.

Genetics - 17 Mar 2025

Shastry Vivaswat, Berg Jeremy J

Abstract excerpt

For many problems in population genetics, it is useful to characterize the distribution of fitness effects (DFE) of de novo mutations among a certain class of sites. A DFE is typically estimated by fitting an observed site frequency spectrum (SFS) to an expected SFS given a hypothesized distribution of selection coefficients and demographic history. The development of tools to infer gene trees from haplotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39698825
DOI: 10.1093/genetics/iyae211
PMCID: PMC11912868

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