The Effects of Mutation and Recombination Rate Heterogeneity on the Inference of Demography and the Distribution of Fitness Effects.

doi:10.1093/gbe/evae004

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Article

The Effects of Mutation and Recombination Rate Heterogeneity on the Inference of Demography and the Distribution of Fitness Effects.

Genome biology and evolution - 1 Feb 2024

Soni Vivak, Pfeifer Susanne P, Jensen Jeffrey D

Abstract excerpt

Disentangling the effects of demography and selection has remained a focal point of population genetic analysis. Knowledge about mutation and recombination is essential in this endeavor; however, despite clear evidence that both mutation and recombination rates vary across genomes, it is common practice to model both rates as fixed. In this study, we quantify how this unaccounted for rate heterogeneity may impact...

Topics

Selection, Genetic
Demography
Mutation
Genetic Drift
Recombination, Genetic
Models, Genetic

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Identifiers

PMID: 38207127
DOI: 10.1093/gbe/evae004
PMCID: PMC10834165

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