Human demographic history has amplified the effects of background selection across the genome.

Abstract excerpt

Natural populations often grow, shrink, and migrate over time. Such demographic processes can affect genome-wide levels of genetic diversity. Additionally, genetic variation in functional regions of the genome can be altered by natural selection, which drives adaptive mutations to higher frequencies or purges deleterious ones. Such selective processes affect not only the sites directly under selection but also...

Topics

• Demography
• Evolution, Molecular
• Gene Frequency
• Genetic Drift
• Genetic Variation
• Genetics, Population
• Genome, Human
• Humans
• Models, Genetic
• Selection, Genetic