A generalized structured coalescent for purifying selection without recombination.

Abstract excerpt

Purifying selection is a critical factor in shaping genetic diversity. Current theoretical models mostly address scenarios of either very weak or strong selection, leaving a significant gap in our knowledge. The effects of purifying selection on patterns of genomic diversity remain poorly understood when selection against deleterious mutations is weak to moderate, particularly when recombination is limited or...

Topics

• Selection, Genetic
• Recombination, Genetic
• Models, Genetic
• Genetics, Population
• Genetic Variation
• Haploidy
• Mutation
• Evolution, Molecular