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Article

Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?

Arthritis research & therapy - 15 Feb 2021

Kvacskay Peter, Yao Nina, Schnotz Jürgen-Heinz, Scarpone Roberta, Carvalho Rui de Albuquerque, Klika Karel D, Merkt Wolfgang, Tretter Theresa, Lorenz Hanns-Martin, Tykocinski Lars-Oliver

Abstract excerpt

BACKGROUND: A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerbation of synovitis in RA, little is known about their influence on the metabolism of SF. Thus, this study investigates the effect of Th cells on the glucose metabolism and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33588937
DOI: 10.1186/s13075-021-02437-7
PMCID: PMC7883459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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