Article
The genetic landscape of Alzheimer disease.
Handbook of clinical neurology - 1 Jan 2018
Carmona Susana, Hardy John, Guerreiro Rita
Abstract excerpt
Alzheimer disease (AD), a progressive and neurodegenerative disease, is the most common form of dementia with high incidence in elderly people. Neuropathologically the disease is defined by the combined presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles of phosphorylated tau protein. Genetically, the first clues were provided by genetic linkage studies that led to the...
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