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Article

MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model.

Scientific reports - 11 Feb 2021

Sakamoto Hiroki, Miyanishi Koji, Tanaka Shingo, Ito Ryo, Hamaguchi Kota, Sakurada Akira, Sato Masanori, Kubo Tomohiro, Osuga Takahiro, Murase Kazuyuki, Takada Kohichi, Nakabeppu Yusaku, Kobune Masayoshi, Kato Junji

Abstract excerpt

Non-alcoholic steatohepatitis (NASH)-related HCC is associated with oxidative stress. However, the mechanisms underlying the development of NASH-related HCC is unclear. MUTYH is one of the enzymes that is involved in repair of oxidative DNA damage. The aim of this study was to investigate the association between MUTYH and NASH-related hepatocarcinogenesis. MUTYH wild-type (Mutyh+/+), heterozygous (Mutyh+/-), and...

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Share to Carcinogenesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33574380
DOI: 10.1038/s41598-021-83138-8
PMCID: PMC7878918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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