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Article

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma.

Free radical biology & medicine - 1 Dec 2018

Sakurada Akira, Miyanishi Koji, Tanaka Shingo, Sato Masanori, Sakamoto Hiroki, Kawano Yutaka, Takada Kohichi, Nakabeppu Yusaku, Kobune Masayoshi, Kato Junji

Abstract excerpt

BACKGROUND & AIMS: The role of base excision repair genes in human hepatocarcinogenesis has not yet been explored. Here, we investigated relationships between variants of these genes and the risk of developing hepatocellular carcinoma (HCC). METHODS: Nineteen tagging SNPs in base excision repair genes (including MUTYH, OGG1 and MTH1) were genotyped using iPLEX assays; one significant SNP was found and confirmed...

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Identifiers

PMID: 30218772
DOI: 10.1016/j.freeradbiomed.2018.09.010

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