Article
MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis.
Cancer research - 15 Jul 2007
Sakamoto Katsumi, Tominaga Yohei, Yamauchi Kazumi, Nakatsu Yoshimichi, Sakumi Kunihiko, Yoshiyama Kaoru, Egashira Akinori, Kura Shinobu, Yao Takashi, Tsuneyoshi Masazumi, Maki Hisaji, Nakabeppu Yusaku, Tsuzuki Teruhisa
Abstract excerpt
MUTYH is a mammalian DNA glycosylase that initiates base excision repair by excising adenine opposite 8-oxoguanine and 2-hydroxyadenine opposite guanine, thereby preventing G:C to T:A transversion caused by oxidative stress. Recently, biallelic germ-line mutations of MUTYH have been found in patients predisposed to a recessive form of hereditary multiple colorectal adenoma and carcinoma with an increased...
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