Article
Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors.
Cancer research - 1 May 2004
Xie Yali, Yang Hanjing, Cunanan Cristina, Okamoto Kimberly, Shibata Darryl, Pan Janet, Barnes Deborah E, Lindahl Tomas, McIlhatton Michael, Fishel Richard, Miller Jeffrey H
Abstract excerpt
Oxidative DNA damage is unavoidably and continuously generated by oxidant byproducts of normal cellular metabolism. The DNA damage repair genes, mutY and mutM, prevent G to T mutations caused by reactive oxygen species in Escherichia coli, but it has remained debatable whether deficiencies in their mammalian counterparts, Myh and Ogg1, are directly involved in tumorigenesis. Here, we demonstrate that deficiencies...
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