Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic control of the human brain proteome.

American journal of human genetics - 4 Mar 2021

Robins Chloe, Liu Yue, Fan Wen, Duong Duc M, Meigs Jacob, Harerimana Nadia V, Gerasimov Ekaterina S, Dammer Eric B, Cutler David J, Beach Thomas G, Reiman Eric M, De Jager Philip L, Bennett David A, Lah James J, Wingo Aliza P, Levey Allan I, Seyfried Nicholas T, Wingo Thomas S

Abstract excerpt

We generated an online brain pQTL resource for 7,376 proteins through the analysis of genetic and proteomic data derived from post-mortem samples of the dorsolateral prefrontal cortex of 330 older adults. The identified pQTLs tend to be non-synonymous variation, are over-represented among variants associated with brain diseases, and replicate well (77%) in an independent brain dataset. Comparison to a large study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autopsy
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Proteome

Share to Proteomics

Share to Quantitative Trait Loci

Share to RNA, Messenger

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 33571421
DOI: 10.1016/j.ajhg.2021.01.012
PMCID: PMC8008492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic control of the human brain proteome.PMID 33571421Read ↗

Genetic control of the human brain proteomeSemantic proximity Read ↗

Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders.Semantic proximity Read ↗

Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disordersSemantic proximity Read ↗

Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk.Semantic proximity Read ↗

Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.Semantic proximity Read ↗

Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric DisordersSemantic proximity Read ↗

Proteome-wide Association Study Provides Insights Into the Genetic Component of Protein Abundance in Psychiatric Disorders.Semantic proximity Read ↗

Shared mechanisms across the major psychiatric and neurodegenerative diseases.Semantic proximity Read ↗

A Multi-Context Regulome-Wide Association Atlas for Genetic Studies of Aging Brain DisordersSemantic proximity Read ↗

Genomic and multi-tissue proteomic integration for understanding the biology of disease and other complex traitsSemantic proximity Read ↗

Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults.Semantic proximity Read ↗

The genetics of neuropsychiatric diseases: looking in and beyond the exome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.