Article

Genetic control of the human brain proteome

2019-10-24

Abstract excerpt

Alteration of protein abundance and conformation are widely believed to be the hallmark of neurodegenerative diseases. Yet relatively little is known about the genetic variation that controls protein abundance in the healthy human brain. The genetic control of protein abundance is generally thought to parallel that of RNA expression, but there is little direct evidence to support this view. Here, we performed a la...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1144f2a0-9eb0-50a1-b364-8b1943fc1426
DOI: 10.1101/816652

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic control of the human brain proteomeDOI 10.1101/816652Read

Genetic control of the human brain proteome.Semantic proximity Read

Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders.Semantic proximity Read

Mapping the serum proteome to neurological diseases using whole genome sequencing.Semantic proximity Read

Proteome-wide Association Study Provides Insights Into the Genetic Component of Protein Abundance in Psychiatric Disorders.Semantic proximity Read

Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disordersSemantic proximity Read

Genomic and multi-tissue proteomic integration for understanding the biology of disease and other complex traitsSemantic proximity Read

Genomic and multi-tissue proteomic integration for understanding the biology of disease and other complex traitsSemantic proximity Read

Integrating Next-Generation Genomic Sequencing and Mass Spectrometry To Estimate Allele-Specific Protein Abundance in Human Brain.Semantic proximity Read

TOPMed imputed genomics enhances genomic atlas of the human proteome in brain, cerebrospinal fluid, and plasma.Semantic proximity Read

Variation and genetic control of protein abundance in humans.Semantic proximity Read

Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome.Semantic proximity Read

Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric DisordersSemantic proximity Read