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Article

Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk.

Nature communications - 28 Nov 2025

Liang Qiuman, Jiang Yi, Shieh Annie W, Zhou Dan, Chen Rui, Wang Feiran, Xu Meng, Niu Mingming, Wang Xusheng, Pinto Dalila, Wang Yue, Cheng Lijun, Vadukapuram Ramu, Zhang Chunling, Grennan Kay, Giase Gina, White Kevin P, Peng Junmin, Li Bingshan, Liu Chunyu, Chen Chao, Wang Sidney H

Abstract excerpt

Genetic variants influencing gene expression have been extensively studied at the transcriptional level. How these variants affect downstream processes remains unclear. We quantitated ribosome occupancy in prefrontal cortex samples from the BrainGVEX cohort and integrated these data with transcriptomic and proteomic profiles from the same individuals. Through cis-QTL mapping, we identified genetic variants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41315269
DOI: 10.1038/s41467-025-65818-5
PMCID: PMC12663470

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