Article
Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.
Nature genetics - 1 Sept 2025
Wingo Aliza P, Liu Yue, Vattathil Selina M, Gerasimov Ekaterina S, Mei Zhen, Ravindran Suda Parimala, Liu Jiaqi, Shantaraman Ananth, Seifar Fatemeh, Wang Erming, Zhang Bin, Reddy Joseph, Allen Mariet, Ertekin-Taner Nilüfer, De Jager Philip L, Fox Edward J, Duong Duc M, Epstein Michael P, Cutler David J, Levey Allan I, Bennett David A, Seyfried Nicholas T, Wingo Thomas S
Abstract excerpt
To understand shared and ancestry-specific genetic control of brain protein expression and its ramifications for disease, we mapped protein quantitative trait loci (pQTLs) in 1,362 brain proteomes from African American, Hispanic/Latin American and non-Hispanic white donors. Among the pQTLs that multiancestry fine-mapping MESuSiE confidently assigned as putative causal pQTLs in a specific population, most were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.